Have you ever wondered if there was a simple blood test that you could do that would tell you if you have a cancer starting to grow in your body? A test that would pick up the cancers years before it would be picked up by normal conventional means?

Introducing the Oncoblot test. This test can detect small amounts of the ENOX protein. This is a substance that lives on the cell membrane of every cell. Normally, small amounts of it is shed into the blood and can now be detected.

Oncoblot detects ENOX2

There are two types of ENOX proteins, ENOX1 and ENOX2. ENOX1 is found in normal cells. These cells exhibit normal controlled growth which is dependent on certain hormones circulating within your blood.

ENOX2 protein is only found in cancer cells. These cells reproduce with uncontrolled growth for they do not respond to normal hormone regulation. Thus, the cancer cells grow, reproduce rapidly, and form into malignant tumors, i.e. cancer.

We can now detect the ENOX2 protein in your blood with the Oncoblot test. Not only can it detect that you have a cancer in your body that is just beginning, but it can also help to determine the tissue type of cancer cells so you can locate from where the malignant cells are coming.

For those who want to know, ENOX is an abbreviation of Ecto Nicotinamide Dinucleotide Oxidase disulfide. It is necessary for proper metabolism and for breaking disulfide bonds and converting NAD to NADP within your mitochondria, which are the energy producers of your body. If this conversion does not occur, the mitochondria won’t work, which can result in cell death, otherwise apoptosis.

How the test detects cancers

In normal cells, ENOX1 leaks from the cells after it is used up within the cells and it then can be found in the blood stream. In cancer cells, as mentioned, ENOX2 is formed by the cancer cells and also leaks into the blood. ENOX2 is not normally found in the blood. Once in the blood, we can detect it and therefore let you know if a small cancer is starting to form within your body. And, since each tissue is different and makes a specific ENOX2, we can detect the tissue of origin and instigate actions to kill the cancer cells.

The test is very sensitive and specific

The overall sensitivity of the test is extremely good, showing that it can detect a cancer with >95% probability.[1] There are very few false positives, <1%, which means the chance of the test showing a positive yet there are no cancer cells present has been confirmed to be <1%. Alternatively, there are also very few false negatives, <1%; meaning the chance of the test showing a negative yet there is a small cancer present is also <1%. The accuracy of diagnosing the correct tissue type is 96%, which is excellent.

Comparison with other screens

Let’s compare the Oncoblot test to a screen we are all familiar with: the mammogram. There is no question that mammograms have been very successful at detecting breast cancers at a very early stage, even before we can palpate (or feel) a lump in the breasts. Mammogram pick up breast cancers when 1 billion cancer cells are present to form the lump, or when the tumor is around 10-20 mm in size.

Conversely, the Oncoblot ENOX2 blood test can detect the breast cancer when 2 million cancer cells are present, or when the tumor is around 0.8 to 2 mm in size. Thus, this test potentially could detect a cancer 5 to 7 years before it is symptomatic. This can include not only breast cancer, but at least 26 other cancers such as lung, colon, pancreatic, prostate and ovarian cancers. A recent article confirmed the ENOX2 presence in Mesothelioma patients 4 to 10 years before the cancer was present clinically [3] . Another article showed the presence of ENOX2 in other cancers, including breast cancer and ovarian cancer, several years before the cancer was clinically evident; i.e. could be picked up by conventional methods. [4]

You only need to do a blood test

To have the test performed, you only need to draw a sample of blood from your arm. The blood is then specially prepared and then sent to a specialized lab which then performs the Oncoblot test. The results come back within a few weeks. It’s as easy as that.

How the test can be used

There are many potential uses for this test. First, as a screen, if negative it can give you reassurance that you don’t have a cancer. If positive, you can take actions to decrease the growth of the cancer when it is barely viable. These could be boosting your ability to naturally fight off and kill the cancer cells before they have a chance to grow. For example, one way is to boost your immune system to do so.

Second, if positive, it can detect the cancer tissue of origin so that specific treatment for that organ/tissue can be instigated. For example, there have been studies suggesting that very high doses of Green tea extract and Capsaicin supplementation could inhibit ENOX2 production without affecting normal cells; i.e. they could kill the cancer cells early.[2]

Third, if you had a cancer in the past, you could monitor its recurrence. Say for instance you had a breast cancer and had treatment performed. It is now 5 years later and you have been told that the conventional tests show no recurrence: you’re cancer free. But are you really? Many people are still concerned they may still have some cells present within their bodies. If you did the Oncoblot test, you would have even more confirmation that no further cancer cells are present. This knowledge could open the door for you to improve your quality of life through further anti-aging actions such as hormone replacement therapy.

Fourth, if you had other possibly positive cancer screens, it could confirm or negate the presence of a cancer. For instance, men are screened for prostate cancer by doing PSA blood tests. If positive, biopsies and further evaluations are performed. Many women have abnormal mammograms and further evaluation is necessary including possibly biopsies. By doing the Oncoblot test, a negative test may help prevent you from having to do such biopsies.

Insurance coverage

At the present time, insurance does not cover the test. The cost of the test is around $1200. If you want peace of mind that you do not have a cancer forming within your body and are willing to do something about an early cancer if it is positive, it could save you thousands of dollars and years of misery; not to mention prevention of a shortening of your lifespan.

In addition, the test is not yet approved by the FDA. A 510 (k) application has been submitted to them and is in progress. It currently meets FDA requirements for Laboratory Developed Test (LDT). But, since not approved by the FDA, it is not covered under insurance.

Once you have done the test, you don’t need another test for several years, so this is not a test that needs to be performed yearly. It is totally elective, and therefore it is up to you to decide to do the test as a preventive action. Consider doing it every 5 years or so if negative, but if you have family history of cancer or other potential problems that could increase your risks of developing cancer, consider doing it more often.

Where to do the test

At TrueMD, we offer the Oncoblot test at our office. We can draw the blood at our office, or you can go to a blood draw station and, for a fee, they can draw the blood and send it off. Call us at 817-399-8783 for further information about the test.

References:

[1] Morre,DJ, Gilmartin, DS. “Estimation of the Accuracy of the ONCOblot Tissue of Origin Cancer test”. ONCOblot Reports, Vol 1,No.1, May, 2015 http://oncoblotlabs.com/wp-content/uploads/2015/06/ONCOblot-Reports-Vo1.-1-No.-1-May-2015.pdf

[2] Hanau,C, et al. “Cancer prevention trial of a synergistic mixture of green tea concentrate plus Capsicum (CAPSOL-T) in a random population of subjects ages 40-84” Clin Proteomics. 2014, Jan 6;11(1).2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901999/

[3] Morre,DJ, et al. “ENOX2-based detection (ONCOblot) of asbestos-induced malignant mesothelioma 4-10 years in advance of clinical symptoms.” Clinical Proteomics 2016,13:2. https://clinicalproteomicsjournal.biomedcentral.com/articles/10.1186/s12014-016-9103-3

[4] Morre, DJ, Taggart,D, Morre,DM. Expression of the ENOX2 Serum Cancer Marker in Advance of Clinical Symptoms. Oncoblot Reports. April 2016; 2(4).file:///C:/Users/Robert/Downloads/2016-04%20ONCOblot%20Reports%20Vol.%202.4%20Early%20ENOX2%20Expression%20(1).pdf