Testosterone may help you decrease your weight and help prevent you from developing diabetes. This protection could thus help decrease your risk of developing many associated medical problems and may thus prolong your life while improving your quality of life.
A long term study carried out by Maimonides Medical Center in New York City, showed benefits of Testosterone Replacement Therapy (TRT) on metabolic syndrome, a precursor disorder to diabetes. Low testosterone has been shown to increase the co-morbidity (additional disorders) to this primary disease. Low testosterone levels late in life, called late-onset hypogonadism (LOH) , is a medical disorder from decreased functional activity of gonads resulting in lower amounts of testosterone. The study was presented in a meeting of American Urological Association (AUA)
Two other reports at the AUA meeting showed improved glucose control and a reduction in lower urinary tract symptoms (LUTS) among the men receiving TRT.
The data from the first study showed that for 261 selected men who had TRT for LOH, the proportion of these 261 men with metabolic syndrome (additional disorder) declined from 56% to 30%, a decline of about 50%, during the long follow-up period of 57 months.
Payam Hakimian, MD, and colleagues of the study group thus hypothesized that TRT would have beneficial outcome on the various components of metabolic syndrome. Based on the criteria of the International Diabetes Federation, the investigators defined metabolic syndrome as the presence of central obesity plus two of the following:
Reduced high density lipoprotein (HDL)
Elevated blood pressure
Elevated fasting plasma glucose
The study group selected 261 men from three general practice clinics in collaboration with colleagues in Germany to test their hypothesis.
“These 261 men had LOH with a serum testosterone level ‰¤3.5 ng/mL and symptoms of erectile dysfunction (International Index of Erectile Function score <21). The men received intramuscular testosterone undecanoate (1,000 mg) at baseline, 6 weeks later and then once every 3 months. Components of the metabolic syndrome were assessed at every follow-up visit.
Beginning at 3 months, the proportion of men meeting diagnostic criteria for metabolic syndrome declined as serum testosterone levels increased. The cohort’s mean testosterone levels stabilized between 6 months and 1 year and remained stable to the end of follow-up.
The cohort (group) had a mean follow-up of 4.25 years. The resolution of metabolic syndrome was accompanied by significant declines in triglycerides (P=0.00), glucose (P=0.00), and mean arterial pressure (P=0.00), and a significant increase in HDL (P=0.05). Additionally, the mean waist circumference decreased by 11 cm.”
The study group carried out a second study of 64 men who had diabetes along with LOH. These men were subjected to same TRT regimen for the same duration.
The findings were – “The cohort’s glucose values decreased from 150.1 to 95.4 mg/dl and mean HbA1c from 8.5% to 5.9%. Men who lost weight had significantly lower mean glucose values at more than half of the follow-up visits compared with men who did not lose weight. A similar pattern was observed in the comparison of men whose waist circumference declined versus those whose waist did not change or increased.”
As per Propa Ghosh,MD of the study group, the findings suggest that TRT improves diabetes control indirectly.
In the third study the effect of TRT on Lower Urinary Tract Symptoms (LUTS) was studied using the International Prostate Symptom Score (IPSS). The hypothesis in this case was that “TRT would improve LUTS irrespective of its effect on body weight or use of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil (Levitra) for erectile dysfunction.”
The study included 130 men with LOH and erectile dysfunction and they were subjected to the same TRT regimen as in the other two studies. The results showed IPSS decreased linearly with time with the rising testosterone levels. The mean IPSS of men were found to have no relation to whether the men gained or lost weight or whether the men used PDES inhibitor or not.
Regarding TRT and LUTS, Youssef El Douaihy, MD, of the study group stated that “the physiological mechanism underlying the association between TRT and LUTS is unclear and deserves further research aimed at clarifying the association,”
Irwin Goldstein,MD at San Diego Sexual medicine in California was appreciative of the studies on TRT by Maimonides group during discussion of the presentations of these studies and noted the lack of mechanistic (biological) research to support the clinical use despite availability of many testosterone products. He also noted absence of publications and presentations on the science of testosterone so far and wished some action on it.
This study confirms our philosophy regarding hormone therapy. Thus, at True Aesthetics Center, we strive to enhance your natural beauty both inside and out, including maintaining adequate levels of hormones. Testosterone for men and testosterone plus estradiol pellets are mainstays of our Hormone Vitality Plus program. Together with losing weight, using our A Special Medication True Diet, these therapies can help improve your health, help you to live happier and longer with better quality of life. For more information, click on the links above.
[Source: This write up is sourced from the article “Testosterone Replacement Has Health Benefits” by Charles Bankhead, Staff Writer, MedPage Today Published May 25,2012]